GLIOBLASTOM - Anni Hofmann Stiftung

Topic: Immunological changes and adaptation of the tumor microenvironment during glioblastoma progression

Head of the project: Prof. Dr. Christel Herold-Mende, Division of Experimental Neurosurgery, Department of Neurosurgery, University Hospital Heidelberg

Prof. Herold-Mende has a long-standing expertise in studying the influence of the immune system on the progress of cancers as the basis for the development of immunotherapies.

In this regard a subset of white blood cells, so-called T cells, plays a major role.

Upon appropriate activation they are able to recognize defined structures on tumor cells and to destroy them subsequently. Migration of such T cells in the tumor tissue can be compromised by the tumor cells themselves as well as by the respective tumor microenvironment.

Aim of this project is the detailed analysis of the migration of T cells into glioblastoma tissues at different points in time of the disease with special emphasis on the role of the tumor microenvironment in this process.

In addition, tumor structures should be identified, which are recognized by the patient’s own T cells and which are still present in recurrent tumors. Especially such antigens would be most suitable for the development of effective immunotherapies.

The complete project description can be found here.