GLIOBLASTOM - Anni Hofmann Stiftung

Project: Relevance of tumor metabolism for the interaction between tumor cells and brain

Project title: Relevance of tumor metabolism for the interaction between tumor cells and brain

Principal investigator: Prof. Dr. med. Katrin Lamszus, Laboratory for Brain Tumor Biology, Dept. of Neurosurgery, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
 
Tumor-specific metabolic processes play an important role in the interaction of tumor cells with the host tissue, specifically in the invasive destruction of the tissue by migrating and invading tumor cells.  It is a specific property of tumor cells to generate energy predominantly through glycolysis, even when oxygen is abundant (normoxia) and metabolize glucose to lactate. This phenomenon (Warburg effect) was originally discovered by Otto Warburg and is of high scientific interest since it offers therapeutic targeting opportunities.

In previous work on glioblastoma cells we discovered an oxygen concentration-dependent metabolic switch between the pentose phosphate pathway (PPP) and glycolysis (Kathagen et al., Acta Neuropathologica 2013).

The PPP is an alternative pathway to the preparatory phase of glycolysis. It is an anabolic pathway, whose function is the production of ribose-5-phosphate for DNA/RNA synthesis and NADPH for fatty acid synthesis and reduction of glutathione.

The full description you will find here.